Product Name :
OPA1 Recombinant Rabbit Monoclonal Antibody [JM81-35]
Predicted band size :
Observed band size :
Synonyms:
Dynamin like 120 kDa protein antibody Dynamin like 120 kDa protein, mitochondrial antibody Dynamin-like 120 kDa protein, form S1 antibody FLJ12460 antibody Juvenile kjer type optic atrophy antibody KIAA0567 antibody KJER type antibody Large GTP binding protein antibody largeG antibody MGM1 antibody 展开
Function :
Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission .Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion.Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation.The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes.Plays a role in remodeling cristae and the release of cytochrome c during apoptosis.Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. Plays a role in mitochondrial genome maintenance.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human OPA1 aa 896-945 / 960.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Tissue, IHC-P, FC
Coupling :
unconjugated
Clone number:
JM81-35
RRID:
AB_3070618
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.Formula of SulfoxFluor 4), 0.82979-45-1 web 05% BSA, 40% Glycerol.PMID:33601901 Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 112 kDa
Positive control :
Mouse testis tissue lysate, PC-12 cell lysate, mouse brain tissue lysate, Hela, SH-SY5Y, SW480, rat skeletal muscle tissue, human thyroid tissue, human kidney tissue, mouse brain tissue.