Product Name :
3-epi-25-Hydroxyvitamin D3 (CAS 73809-05-9)
Synonym :
Application :
CAS:
73809-05-9
Purity:
Molecular Weight:
400.64
Formula :
C27H44O2
Physical state:
Solid
solubility :
Shipping Condition :
Store at -80° C
Melting point:
63-68° C
SMILES:
CC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
References:
:C-3 epimerization of vitamin D3 metabolites and further metabolism of C-3 epimers: 25-hydroxyvitamin D3 is metabolized to 3-epi-25-hydroxyvitamin D3 and subsequently metabolized through C-1alpha or C-24 hydroxylation. | Kamao, M., et al. 2004. J Biol Chem. 279: 15897-907. PMID: 14757768A specific LC/ESI-MS/MS method for determination of 25-hydroxyvitamin D3 in neonatal dried blood spots containing a potential interfering metabolite, 3-epi-25-hydroxyvitamin D3. | Higashi, T., et al. 2011. J Sep Sci. 34: 725-32. PMID: 21328697Isotope dilution ultra performance liquid chromatography-tandem mass spectrometry method for simultaneous measurement of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3 and 3-epi-25-hydroxyvitamin D3 in human serum. | Schleicher, RL., et al. 2011. Clin Chim Acta. 412: 1594-9. PMID: 21601563Fast separation of 25-hydroxyvitamin D3 from 3-epi-25-hydroxyvitamin D3 in human serum by liquid chromatography-tandem mass spectrometry: variable prevalence of 3-epi-25-hydroxyvitamin D3 in infants, children, and adults. | van den Ouweland, JM., et al. 2011. Clin Chem. 57: 1618-9. PMID: 21914787Enhanced 3-epi-25-hydroxyvitamin D3 signal leads to overestimation of its concentration and amplifies interference in 25-hydroxyvitamin D LC-MS/MS assays. | Flynn, N., et al. 2014. Ann Clin Biochem. 51: 352-9. PMID: 24000372Evaluation of 3-epi-25-hydroxyvitamin D3 cross-reactivity in the Roche Elecsys Vitamin D Total protein binding assay.5617-74-3 Computational Chemistry Data | van den Ouweland, JM., et al. 2014. Clin Chem Lab Med. 52: 373-80. PMID: 24108209Overestimation of 25-hydroxyvitamin D3 by increased ionisation efficiency of 3-epi-25-hydroxyvitamin D3 in LC-MS/MS methods not separating both metabolites as determined by an LC-MS/MS method for separate quantification of 25-hydroxyvitamin D3, 3-epi-25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 in human serum.16732-70-0 Molecular Weight | van den Ouweland, JM.PMID:33459922 , et al. 2014. J Chromatogr B Analyt Technol Biomed Life Sci. 967: 195-202. PMID: 25125396Time-course analysis of 3-epi-25-hydroxyvitamin D3 shows markedly elevated levels in early life, particularly from vitamin D supplementation in preterm infants. | Ooms, N., et al. 2016. Pediatr Res. 79: 647-53. PMID: 26709675Enhancing analysis throughput, sensitivity and specificity in LC/ESI-MS/MS assay of plasma 25-hydroxyvitamin D3 by derivatization with triplex 4-(4-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues. | Ogawa, S., et al. 2017. J Pharm Biomed Anal. 136: 126-133. PMID: 28081498Investigation of the C-3-epi-25(OH)D3 of 25-hydroxyvitamin D3 in urban schoolchildren. | Berger, SE., et al. 2018. Appl Physiol Nutr Metab. 43: 259-265. PMID: 29053944Catalytic properties of 25-hydroxyvitamin D3 3-epimerase in rat and human liver microsomes. | Tuckey, RC., et al. 2019. Arch Biochem Biophys. 666: 16-21. PMID: 309264333-Epi-25-hydroxyvitamin D3 is a poor substrate for SULT2A1: Analysis of its 3-sulfate in cord plasma and recombinant human SULT2A1 incubate. | Yoshimura, Y., et al. 2020. Steroids. 162: 108695. PMID: 32649998Measurement of plasma 25-hydroxyvitamin D2, 25-hydroxyvitamin D3 and 3-epi-25-hydroxyvitamin D3 in population of patients with cardiovascular disease by UPLC-MS/MS method. | Abouzid, M., et al. 2020. J Chromatogr B Analyt Technol Biomed Life Sci. 1159: 122350. PMID: 32890769